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  • br The anesthetic analgesic drugs mainly

    2020-08-18


    The anesthetic analgesic drugs mainly used in the Study include Morphine Hydrochloride Injection, Tramadol Injection, Dezocine Injection, Morphine Hydrochloride Sustained-release Tablets, Tra-madol Hydrochloride Sustained-release Tablets, Oxycodone Hy-drochloride Sustained-release Tablets and Fentanyl Transparent Dressing. Among them, morphine prescription, as a common clin-ical analgesic, plays an important role in cancer pain analgesia.
    Table 2
    Use analysis of anesthetic analgesic drugs in patients with cancer pains.
    Name of anesthetic drugs Total dosage Defined daily DDDs Medication DUI
    Morphine Hydrochloride Sustained-release Tablets have the high-est total dosage, followed by Tramadol Hydrochloride Sustained-release Tablets, and Dezocine Injection has the lowest total dosage. The analgesic effect of Morphine Hydrochloride Sustained-release Tablets is significant, which takes effect rapidly, especially for persistent pain. The analgesic effect of morphine for one admin-istration can be maintained for 4 min to 6 h (t = 1.73 h). It could be maintained for a long time, and the drug would not ac-cumulate in vivo, which is metabolized via liver and eliminated via kidney. Therefore, the drug shall be used carefully by the patients with abnormal liver and kidney function. Dezocine is a K receptor agonist and µ receptor antagonist, which is subcutaneously and intramuscularly injected and can take effect within 30 min. It has a significant effect on postoperative pain and cancerous pain. The drug has little addiction and higher safety, so it is used most in clinical tumor analgesia.
    Relevant experts of WHO believe that morphine, as strong opi-oid representative drugs, can effectively alleviate the pain symp-toms of patients and they consider that the best way for analgesia in patients with cancer pain is to take morphine orally for long time. Morphine Hydrochloride Sustained-release Tablets and Mor-phine Hydrochloride Injection are the morphine drugs commonly used. After entering the body, Morphine Hydrochloride Sustained-release Tablets release slowly and steadily, with a lower value of Exendin4 drug concentration peak, and the analgesic effect is remarkable. Morphine Hydrochloride Injection has a wide range of distribution and takes effect quickly, which can play an analgesic effect in a short time. Pethidine is a common analgesic drug used by doctors in non-tumorous department. The analgesic effect of the drug is rapid, but the holding time is short. It requires repeated use in clinical and the metabolite of Pethidine-Norpethidine (AjZ) has central neurotoxicity. Long-term repeated use of drugs may result in the accumulation of drugs in vivo. Therefore, it is not recommended by WHO for the treatment of cancer pain. It is shown from DUI analysis results in the Study that the
    DDD of Fentanyl Transparent Dressing is the highest, followed by Morphine Hydrochloride Sustained-release Tablets and that of Dezocine Injection is the lowest. According to DUI, Oxycodone Hydrochloride Sustained-release Tablets is used most reasonably, with the lowest DUI, while that of Morphine Hydrochloride Sustained-release Tablets is the highest. The main reason is that morphine is widely used in clinical analgesia, with significant analgesic effect, and the clinicians often use it as the main analgesic drug for patients with cancer pain. Fentanyl Transparent Dressing is suitable for patients who cannot take oral medicine or who need painkiller for a long time but cannot tolerate intramuscular injec-tion. It has sedative effect and can release fentanyl continuously and systematically within 72 h at a constant release rate, which can also maintain stable plasma drug concentration. Oxycodone Hydrochloride Sustained-release Tablets has significant effect on the patients with persistent light and moderate pains, of which the bioavailability is 60%∼90%. After entering the body, 38% of the drug releases immediately and 62% of the drug releases slowly. The analgesic effect is persistent and high, which was twice the analgesic effect of morphine. 
    References
    [1] M.X. Zhu, G.R. Zhou, W. Wei, Influence of anesthesia and analgesia methods on postoperative lower respiratory tract infections in gastric cancer patients, Chin. J. Nosocomiol. (2015). [2] L.R. Shen, G.U. Chen-Ze, Y.H. Ding, et al., Influence of combined acupuncture and drug anesthesia on postoperative analgesic effect in intestinal cancer patients, Shanghai J. Acupuncture Moxibustion (2011).
    [3] S.H. Zhu, X.L. Wang, L.I. Ping, et al., Clinical observation of analgesic effect of strong opioid drugs for moderate and severe cancer pain in patients with different gastrointestinal function, J. Digestive Oncol. (2015).